Ligand-protein pairs

Refining Ligand-Protein Pairs Bumps and Holes ... 

Hex Hex [40] is a free software used to study the docking modes of proteins and ligands, protein pairs, and DNA molecules. It is an interactive molecular graphics program which can be downloaded or performed online. It uses the spherical polar Fourier (SPF) correlations for the docking calculations (Fig. 4.52). 

Fig. 8.1 Schematic diagram showing how a naturally occurring small molecule ligand-protein interaction is changed to create an orthogonal ligand-receptor pair.

Both of these strategies have broader applications than the kinase signaling pathways. Orthogonal ligand-receptor pairs could, theoretically, be made for any ligand-receptor pair. These pairs could then be used to study metabolic pathways and protein function, to identify smaD-molecule ligands and other applications. 

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