Promiscuous ligands

Ekroos, M. and Sjogren, T. (2006) Structural basis for ligand promiscuity in cytochrome P450 3 A4. Proceedings of the National Academy of Sciences of the United States of America, 103, 13682-13687. 

Ekroos M, Sjogren T (2006) Stmctural basis for ligand promiscuity in cytochrome P450 3A4. Proc Natl Acad Sci U S A 103 13682-13687... 

Note PI3K assays will vary according to the type of T-cell model employed and concentration of chemokine assayed. For clarity, activation of PI3K by chemokines that show promiscuity toward receptors is attributed to signaling via all the receptors bound by these ligands, even though such details have not necessarily been investigated. 

Chemokines exhibit complex ligand-receptor relationships. Often, individual chemokines can bind productively to more than one receptor, and many chemokine receptors can signal in response to more than one chemokine. Usually, these chemokine receptors bind multiple chemokines within the same subfamily. The best documented example of chemokine receptor promiscuity across subfamilies involves CXCR3 binding to CCL21. 

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