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Ligand dynamics

Another example of the application of lineshape analysis to ligand dynamics is described in Section 4.3 for the drug trimetrexate, which binds to dihydrofolate reductase (DHFR). From that example it is clear that the techniques described above can equally be applied to ligands when bound to their receptors. In some cases significant but highly specific mobility appears to be present at the bound site. [Pg.137]

Time-Resolved Infrared Studies of Ligand Dynamics in Heme Proteins... [Pg.204]

Is chemical exchange or ligand dynamics occurring (via variable temperature or saturation transfer measurements) ... [Pg.6162]

Wang J, Ortiz-Maldonado M, Entsch B, Massey V, Ballou DP, Gatti DL. Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase. Proc. Natl. Acad. Sci. U.S.A. 2002 99 608-613. [Pg.2301]

Ligand Dynamics Line-Shape and Relaxation Data, 528... [Pg.507]

C and H NMR spectroscopy has been extensively used for probing the ligand dynamics of metal-bound Cj hydrocarbyl fragments (65), and many of these processes are now well understood. However, there have been relatively few reports on the fluxional characteristics of Cj allenylic hydrocarbyl units. [Pg.100]

Unusual ligand dynamics in the modified allenyl cluster [Ru,H(CO)i (ju.-i7, rj, 7 --Me2NC=C=CHaHb)] (99) were described by Aime ef al. (56b). [Pg.103]

Chaves, M., E. D. Sontag, and R. J. Dinerstein. 2004. Steady-states of receptor-ligand dynamics A theoretical framework. J Theor Biol 227 413-28. [Pg.374]

See other pages where Ligand dynamics is mentioned: [Pg.290]    [Pg.93]    [Pg.5]    [Pg.14]    [Pg.125]    [Pg.131]    [Pg.923]    [Pg.436]    [Pg.457]    [Pg.3]    [Pg.54]    [Pg.126]    [Pg.132]    [Pg.206]    [Pg.215]    [Pg.220]    [Pg.237]    [Pg.508]    [Pg.39]    [Pg.100]    [Pg.102]    [Pg.103]    [Pg.105]    [Pg.339]    [Pg.207]   


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Ligand, ligands dynamic

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