Ligand dissociation specificity

The short peptide linker ligand is specifically designed to be cleaved by the target enzyme in order to enable enzyme detection. Dissociation of the aggregates... 

Current opinion supports the idea that, in order to trigger the onset of polymerization, dissociation of the donor ligand (L2) must occur. Control over this dissociation process is vital in order to achieve a switchable initiator. As long as the dissociation is slowed down or even prevented, the initiator will exhibit latency. However, a specific event, such as thermal heating, may induce ligand dissociation and initiation of the polymerization. Common structures depicting thermally switchable catalysts are presented in Figure 12.1 [8]. 

Kinetics of ligand dissociation and exchange between binding sites Criteria for specificity... 

During all the discussions of ligand binding, throughout this volume, it has been emphasized that these processes involve at least two steps (1) the formation of a collision complex and (2) a subsequent rearrangement to form the specific complex. As a corollary one should often find two steps in ligand dissociation. Such a situation can be analysed by a simplified model of the two step reversible reaction discussed in section 5.2. If the equilibrium... 

There are many examples of acid catalysis of the dissociation of complexes containing polydentate ligands as designated by category (6). For amine systems such as [Fe(bipy)3] and [Ni(en)3]2 , the catalysis is believed to result from an opening up of the chelate ring followed by protonation of its free end, and then rapid loss of the protonated ligand. A specific example of such a mechanistic scheme is provided by the acid-catalyzed dissociation of [Fe(bipy)3j+, Eq. (42). 

Dissociation constant, the ratio of the rate of offset of ligand away from a receptor divided by the rate of onset of the ligand approaching the receptor. It has the units of concentration and specifically is the concentration of ligand that occupies 50% of the total number of sites available for ligand binding at equilibrium (see Affinity). 

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