Ligand dissociation constants

Goldstein, A., Barrett, R. W Ligand dissociation constants from competition binding assays errors associated with ligand depletion. Mol. Pharmacol. 1987, 13, 603-609. 

Reduction Potentials Measured for Myoglobin and the Four Nitrophorins, and the Derived Ligand Dissociation Constants of the Nitrophorins (49, 50, 55)... 

Species PBP1 Ligand Dissociation constant, Assay3 Kd Reference... 

There is a good correlation between the logarithms of the ligand dissociation constants K (reverse of stability constant) of NiL4 and the cone angles of L. As the cone angle increases, so does the K value ... 

L. Fielding, NMR methods for the determination of protein-ligand dissociation constants, Curr. Topics Med. Chem., 3 (2003) 39-53. 

Table 1 Ligand dissociation constants for yeast ODCase ...

The relative contribution of each interaction was calculated from the ratio of the ligand dissociation constant determined with the mutant enzyme to that determined with wild-type yeast ODCase... 

R 55 L. Fielding, NMR Methods for the Determination of Protein-Ligand Dissociation Constants , p. 39... 

Letting Ka be the acid dissociation constant of the ligand, = c cJcu, which is combined with the definitions Xj = Ci — Ci and Eq. (4-38) to give... 

It can be seen that the equality defined in Equation 4.32 is true only when ICSo = KB (i.e., the concentration of a non-competitive antagonist that reduces the binding of a tracer ligand by 50% is equal to the equilibrium dissociation constant of the antagonist-receptor complex). 

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