Ligand binding of cisplatin

Several studies on models have been reported, both on the binding of a range of metals to apometallothionein and the design of ligands, particularly with Cys-X-Cys and Cys-X-Y-Cys arrangements as found for metallothionein.1163,1164 All metal derivatives appear to bind in metal-thiolate clusters.1149 Platinum has also been found bound to metallothionein in rat tissues following treatment with cisplatin and the trans isomer.1165... 

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