Ligand-based NMR techniques

Protein-based NMR techniques are more powerful than ligand-based techniques in characterizing ligand binding, bnt are mnch less widely applicable because these protein-based techniqnes require both the protein be either... 

In fact, higher molecular-weight proteins enhance the observation of abinding event in a ligand-based NMR screen. All of these characteristics make ligand-based NMR screens a routinely used drug discovery technique. 

Studies of CpLi solutions showed high conductivity, suggesting ionic particles in solution.91 Ionic particles could consist of the free ions, but anionic cyclopentadienides MCp2- particles isoelectronic to the well-known alkaline earth cyclopentadienides Cp2M (M = alkaline earth metal),103 could also be envisioned. Moreover, the structural motif of a sandwich complex where two Cp ligands bind to a metal center is well established throughout the periodic table. Indeed, the Cp2 Li anion was suggested based on NMR techniques,114-116 and... 

Licini, Bonchio and coworkers utilized trialkanol amines as a new class of ligands for the Ti-based catalytic conversion of sulfides to sulfoxides by TBHP or CHP, as shown in Schemes 5 and 10. Only 0.01 equivalent of catalyst is required to reach ee values up to 84% for (S )-sulfoxides. Opposite configurated sulfoxides may be obtained using the Zr(IV)/trialkanol amine combination with ee values in the range 80-90%. The occurrence of a Ti-peroxo derivative oxidizing agent 33 for these transformations has been confirmed also by ESI-MS and NMR techniques ... 

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