Tubocurarine Lidocaine

Mahajan RP, Grover VK, Munjal VP, Singh H. Doubleblind comparison of lidocaine, tubocurarine and diazepam pretreatment in modifying intraocular pressure increases. Can J Anaesth 1987 34(l) 41-5. 

A frequently cited example of an important natural-product-derived drag is the neuromuscular blocker d-tubocurarine, derived from the South American plant curare, which was used by South American Indians as an arrow poison (see Chapter 26). Tubocurarine led to the development of decamethonium, which, although structurally dissimilar to tubocurarine, was nevertheless synthesized based on the then prevalent presumption that tubocurarine contained two quaternary nitrogens. Similarly, synthetic local anesthetics, such as lidocaine, benzocaine, and dibucaine, were synthesized to mimic the nerve-blocking effect of cocaine, a natural alkaloid obtained from the leaves of Coca eroxylum, but without the adverse side effects that have led to its abuse. 

Lidocaine, bupivacaine, mepivacaine, procaine, cocaine Depolarizing D-tubocurarine, atracurium, pancuronium Nondepolarizing succinylcholine... 

Procainamide has been reported to increase the effects of suxamethonium in animals, increase muscle weakness in a myasthenic patient, and reduce plasma cholinesterase activity in healthy subjects. An animal study demonstrated potentiation of the neuromuscular blocking effect of tubocurarine by lidocaine alone and combined with antibiotics having neuromuscular blocking activity (neomycin or polymyxin B). ... 

Interfering alizapride, atracurium, ketamine, ketogan, lidocaine, metoclopramide, nimodipine, prochlorperazine, tubocurarine... 

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