Lidocaine poisoning with

Heroin is usually cut with baking soda, powdered milk, baby powder, sugar, starch, or quinine, but has also known to be cut with lidocaine, curry powder, strychi-nine, and even laundry detergent. Law enforcement officials in New York report the existence of heroin cut with a rat poison from Santa Domingo called Tres Pasos (meaning three steps ). Three is the number of steps the mice take before dying after exposure to the poison. 

Patients with liver disease have an increased susceptibility to certain drugs due to decreased hepatic clearance for drugs metabolized by the liver or due to enhanced sensitivity. For example, impaired hepatic metabolism can precipitate central nervous system (CNS) toxicity in patients on theophylline, phenytoin, or lidocaine or ergot poisoning on ergotamine. ... 

Drug overdose Hemodynamic instabOity and hypotension after massive caffeine overdose improved with loading doses followed by continuous infusions of both phenylephrine and lidocaine [93" ]. Hypotension in caffeine overdose is multifactorial P2-adrenoceptor agonism causes peripheral vasodilatation and Pj-adrenoceptor stimulation leads to profound tachycardia with incomplete diastolic fiUing. The authors suggested that both phenylephrine and lidocaine should be considered in the treatment of cardiovascular collapse secondary to methylxanthine poisoning. 

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