Lidocaine antitussive

Quaternary ammonium salts such as carcainium chloride (RSD 931) have been shown to be antitussive whilst having much reduced local anaesthetic activity. Whilst the molecular mechanisms underlying this antitussive activity is not understood, RSD 931 appears to be A8 fibre selective and may represent a novel class of antitussive drug. More recently JMF2-1 a lidocaine derivative that blocks Na+ channels has had beneficial effects in the airways without significant local anaesthetic activity. 

In 1973, in a multicenter study of 1200 individuals carried out by the North American Contact Dermatitis Group, there was a 3% incidence of delayed hypersensitivity reactions to parabens. General allergic reactions have also been reported after the injection of parabens-containing formulations of lidocaine and hydrocortisone and after oral use of barium sulfate contrast suspension, haloperidol syrup, and an antitussive sjrup, aU of which contained parabens (SEDA-11, 484). 

RSD 931 is a quaternary ammonium compound (carcainium chloride) and a structural analogue of lidocaine, that exhibits antitussive activity in both guinea... 

Trevisani M, Milan A, Gatti R, Zanasi A, Harrison S, Fontana G, Morice AH, Geppetti P (2004) Antitussive activity of iodo-resiniferatoxin in guinea pigs. Thorax 59 769-772 Trochtenberg S (1994) Nebulized lidocaine in the treatment of refractory cough. Chest 105 1592-1593... 

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