Libraries tags, haloaromatic

Figure 1.10. Encoded combinatorial libraries by (A) sequenceable chemical tags (oligonucleotides and peptides) or by (B) non-sequenceable chemical tags (haloaromatic phenol ethers).

Alternatively, each tag may be added individually to the resin [123-129]. In this case, the tags must encode for both the building block structure and the step in the library synthesis (haloaromatics as non sequenceable tags Fig. 1.10.B) [123-127],... 

Molecular tags overcome the chemical sensitivity and orthogonal protection required by both peptide and oligonucleotide encoding. Two such methods have been developed and applied to the synthesis of both peptide and nonoligomeric libraries. One of these [34] approaches uses chemically robust haloaromatic tags which are used in a binary encoding... 

Soo Yoon et al. [32] presented a 50,625-member N-acylated tripeptide library with the structure RESIN-CH2NHCO(CH2)5NH-AA,-AA2-AA3-COR AA, 2 3 were 15 l- or D-amino acids and RCOX were 15 acylating agents. The structure of the haloaromatic tags used, composed by an electrophone tag and by a photosensitive linker, is reported in Figure 5 together with their synthetic pathway. 

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