Libraries, combinatorial privileged structures

Guo, T. and Hobbs, D.W. Privileged structure-based combinatorial libraries targeting G protein-coupled receptors. Assay Drug Dev. Tech. 2003, 1, 579-592. 

Privileged Structures and Substructures in the Design of Pharmacologically Relevant Combinatorial Libraries... 

Nicolaou, K.C. Pfefferkom, J.A. Barluenga, S. Roecker, A.J. Cao, G.-Q. (2000C) Natural product-like combinatorial libraries based on privileged structures. 3. The libraries from libraries principle for diversity enhancement of benzopyran libraries. J. Am. Chem. Soc., 122, 968-76. 

A discussion to the concept of natural product-like combinatorial libraries based on privileged structures and an impressive experimental proof of concept has been disclosed by the Nicolaou group a) K. C. 

Figure 1.6 Structural scaffolds that served as templates for so-called privileged structure-based combinatorial compound libraries. R-groups are depicted at positions of combinatorial variations [45],...

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