LH-Tetrazol

CN (6/ -ci.r)-7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[l-(2-hydroxyethyl)-lH-tetrazol-5-yl]thio]methyl]-... 

CN 2-butyl-4-chloro-l-[[2 -(lH-tetrazol-5-yl)[l,r-biphenyl]-4-yl]methyl]-l//-imidazole-5-methanol monopotassium salt... 

C24H24NSO5S 66510-99-4) see Latamoxef diphenylmethyl 7(/f)-amino-3-(l-methyl-lH-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylate (C23H22N6O3S2 53090-86-1) see Cefbuperazone diphenylmethyl 7-amino-3-[(Z)-f -propenyl]-3-cephem-4-carboxylate... 

S-methyl- lH-tetrazol-1 -yl)henzoic acid (C9HSN4O2 72470-51-0) see Imiquimod A -methyl-2-thenylamine... 

In a recent paper by Salimbeni et al. [2], a novel series of such All antagonists has been presented on the basis of a comparative analysis of theoretical distributions of the electrostatic potential (inactive compounds and overlay studies, employing a computational model of an All active conformation, it was found that the compound named LR-B/081 [3, 4] (C3oH30N603S), i.e. 2-[(6-butyl-2-methyl-4-oxo-5- 4-[2-(lH-tetrazol-5-yl)phenyl] benzyl -3H-pyrimidin-3-yl)methyl]-3-thiophenecarboxylate (Scheme 1), was one of the most potent in the series, and was selected as a candidate for further studies. 

Table 2. Amounts of 5-AT and lH-tetrazole as weight percent relative to total amount of impurities.

Cefpiramide (64) is a third generation cephalosporin with a l-methyl-[lH]-tetrazol-5-ylthio-methyl moiety at C-3 and an acylated p-hydroxyphenylglycine moiety at C-7. It includes in its activity spectrum reasonable potency in vitro against many strains of Pseudomonas. It can be synthesized in a variety of ways including condensation of cephalosporin antibiotic 63 with 6-methyl-4-(l-H)-pyridone-3-carboxylic acid in the form of its active N-hydroxysuccinimide ester (62) to produce cefpiramide (64) [20,21]. 

H(or f )-tetrazole, QHqN-NH-N J, and ethyl group can be placed in position 1 of lH-tetrazole, position 2 of 2H-tettazole and position 5 of 1H- or 2H-tetrazoles (See... 

Ethyltetrozylozide, CaH5N7 mw 139.12, N 70.49% crysts. Prepd by reacting ethyl chloride or sulfate with. an alkali salt of tetrazylazide. No props or structure ate given presumably it is the l-ethyl-5-azido-lH-tetrazole, N(C2HB)— N N— N=CN3... 

Acetonehydrazone-a(lH)- tetrazole, called Acetone 5-tetrazolylhydrazone by Benson, (Tetrazolon-iso-propyliden- hydrazon, in Ger), (CH3)aC N-NH-C.NH-N, mw 140.15,... 

Am ino-l-phenyl-a-tetrazole, 5- Ami no-1-phenyl-lH-tetrazole or l-Phenyl-S-amino-tetrazole [Called in Beil 1-Phenyl-tetrazolon-(5)-imin], H2N C-N(C6H5 )- N. Scales(from... 

Amino-5-(p-nitrophenyl)-a-tetrazole or 1-Amino-5-(4 -nitrophenyl)-lH-tetrazole,... 

Amino-1(p-nitrophenyl)-a-tetrazole, 5-Amino-l-(4-nitrophenyl)-lH-tetrazole or 1-(p-Nitro-phenyl)-5-aminotetrazole, H2N-C-N(C6H4 N02 )-N. 

Amino-a-tetrazole Nitrate or 5-Amino lH-tetrazole Nitrate (called by Hantzsch et al, "Amidotetrazolnitrat ), CHsNs-HNOj, mw... 

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