Levofloxacin warfarin, interaction

Gheno G, Cinetto L. Levofloxacin-warfarin interaction. Eur J Clin Pharmacol 2001 57(5) 427. 

Jones CB, Fugate SE. Levofloxacin and warfarin interaction. Ann Pharmacother 2002 36(10) 1554-7. 

Ravnan SL, Locke C. Levofloxacin and warfarin interaction. Pharmacotherapy 2001 21(7) 884-5. 

Many drug compounds are racemic mixtures of stereoisomers. In most cases, one of the isomers is more pharmacologically active than the other isomer, and each isomer may exhibit different pharmacokinetic properties. Warfarin, propranolol, verapamil, and ibuprofen are aU racemic mixtures of stereoisomers. Some drug interactions inhibit or increase the elimination of only one stereoisomer. The importance of the drug interaction depends on which isomer is affected. Other drugs, such as dextromethorphan, levofloxacin, and dUtiazem, are composed of just one stereoisomer. 

McCall KL, Scott JC, Anderson HG. Retiospective evaluation of a possible interaction between warfarin and levofloxacin. Pharmaco rapy (2005) 25, 67-73. 

Retrospective assessment of potential interaction between levofloxacin and warfarin. Pharm World Sci 2009 31(2) 224-9. 

One case of severe coagulopathy leading to hypovolemic renal failure was caused by the interaction of levofloxacin and warfarin in a 30-year-old man [48 ]. Addition of any medication whilst on warfarin must be carefully monitored. 

Nemoto C, Ikegami Y, Shimada J, Tsukada Y, Abe Y, Tase C. Acute renal failure caused by severe coagulopathy induced by the interaction between warfarin potassium and levofloxacin a case report. J Anesth 2012 26(6) 943-4. 

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