Parkinson’s disease levodopa for

Pyridoxine has both dopamine-enhancing and dopamineblocking properties on the one hand pyridoxine (like dopamine) depresses the release of prolactin from the pituitary gland on the other hand, in oral doses of 10-20 mg it rapidly reverses the therapeutic effect of dopamine (16). This should be borne in mind if pyridoxine is prescribed for nursing mothers or for patients treated with levodopa for Parkinson s disease or syndrome, although the problem does not seem to arise when using the combination of levodopa with decarboxylase inhibitors. 

Pyridoxine (given alone or in combination with vitamin Bn ) may induce a deterioration of an acne vulgaris or an eruption of an acneiform exanthema (22 ). The antagonism between pyndoxine and levodopa is well known. The matter should be borne in mind when prescribing pyAdoxine for patients treated with levodopa for Parkinson s disease or syndrome (23 ). 

---