Lesk: Arthur

Lesk, Arthur M. Introduction to Bioinformatics. 3d ed. New York Oxford University Press, 2008. Comprehensive overview of genomes, proteomics, protein structure, databases, phylogenetics, programming languages, and more. 

Arthur Lesk and Cyrus Chothia at the MRC Laboratory of Molecular Biology in Cambridge, UK, compared the family of globin strucfures with the aim of answering two general questions How can amino acid sequences that are very different form proteins that are very similar in their three-dimensional structure What is the mechanism by which proteins adapt to mutations in the course of their evolution ... 

I appreciate the helpful suggestions made by Dr. Alexander Rich, Prof. Christian Bauer, Dr. Walter Bodmer, Drs. Joseph and Celia Bonaventura, Dr. Sydney Brenner, Prof. Maur-izio Brunori, Dr. H. Frank Bunn, Prof. Patricia H. Clarke, Dr. Thomas E. Creighton, Dr. Richard E. Koehn, Dr. Arthur M. Lesk, Dr. Richard C. Lewontin, Dr. Robin N. Perutz, and Dr. Graham Shelton concerning this paper. To all these colleagues I wish to express my gratitude. 

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