Lesion Recognition by DNA Glycosylases

These three individual enzymes make a number of contacts that favor binding of the substrate and discriminate against binding of nondamaged bases. In UDG, which removes U from DNA, a bifurcated hydrogen bond from Asn204 to 04 and 

Extensive kinetic and structural studies of uracil recognition by UDG have been published mainly by Stivers et al. revealing similarities, but also important differences in how UDG recognizes damaged sites as compared to OGGI [21]. Both enzymes can bind native DNA bases in an exo-site [36]. In the case of UDG, a T 

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