Leroy syndrome

Mucolipidoses are characterized by a combined metabolic disorder of mucopolysaccharides, lipids, and glycoproteins. Lysosomal storage and foamy swollen Kupffer cells with hepatomegaly may be seen. In some of the numerous types, the underlying enzymatic defects have not yet been detected. Type II is also called Leroy syndrome (J.G. Leroy et al., 1967). Due to distinctive cytoplasmic inclusions in fibroblast cultures, this disorder is also known as inclusion cell disease (J.G. Leroy et al., 1971). Foamy altered stellate cells, macrophages and also epithelioid foam cell granulomas are found. 

Demars R, Leroy JG The remarkable cells cultured from a human with Hurler s syndrome an approach to visual selection for in vitro genetic studies. In Vitro 2 107-118,1966. 

HerveJP, LeguyP,CledesJ, Leroy JP. Nephrotic syndrome with minimal glomerular lesions during treatment with D-penIclllamlne. Nouv Press Med 1980 9 2847. 

Dhib M, Bakhache E, Postec E, Vanrenterghem B, LeRoy F, Azar R, Francois A, Boldron A, Amaria R, Ozenne G, Hermelin A. Nephrotic syndrome complicating treatment with interferon a (Original title Syndrome nephrotique compliquant un traitment par interferon a). Press Medicale 1996 25(23) 1066-1068. 

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