Ledum palustre Ledol

Ledol. Decahydro-l,l,4,7.tetrametltyl-lH-cyclo-prop eJazulen-4-ol Ladum camphor", C SH O mol wt 222.36. C 81.02%, H 11.79%, O 7.20%. Occurs in the essen-tial nil from leaves of Ledum palustre L Grassmann, Re-... 

Ledum palustre contains two not really toxic but pharmacologically active compounds, ledol, and palustrol, responsible for poisoning (56). They cause local... 

Ledol and palustrol are two aromadendrane derivatives in the essential oil from Labrador tea Ledum palustre). This oil causes vomiting, gastroenteritis, and excitation in man but is also toxic for animals [9]. Recently, fraganol and fraganyl acetate, rare mmioterpenes, were described as toxic essential oil components in Achillea umbellata [75]. 

Telekin from the roots of Telekia speciosa, helenin from the roots of Inula helenium L., and sesquiterpene alcohol ledol from the aerial parts of Ledum palustre L. show cytotoxicity [41]. Bisabolol, a nontoxic sesquiterpene alcohol, was isolated from Matricaria chamomilla, Carthamus lanatus, and Matricaria recutita and exhibits a cytotoxic apoptosis-inducing effect [42] against human glioblastoma and pancreatic carcinoma cell lines. 

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