Leber hereditary optic neuroretinopathy

Leber hereditary optic neuroretinopathy [18] A rapid bilateral central vision loss due to optic nerve death. The disease has been associated with several missense mutations in the mtDNA that can act autonomously or in association with each other to cause the disease. 

Vilkki J, Savontaus ML, Nikoskelainen EK. Segregation of mitochondrial genomes in a heteroplasmic hneage with Leber hereditary optic neuroretinopathy. Am J Hum Genet 1990 47 95-100. 

Lead poisoning 454 Leber s hereditary optic neuroretinopathy (LHON) 521, 525 Legs... 

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See also in sourсe #XX -- [ ]

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