Scoring leads defined

Sending only qualified leads to sales with lead scoring Defining your lead scoring criteria Creating your lead scoring plan and matrix... 

Once the bone mineral density report is available, T-scores and Z-scores are useful tools in interpreting the data. The T-score is the number of standard deviations from the mean bone mineral density in healthy young white women. Osteoporosis is defined as a T-score at least -2.5 standard deviations below the mean (Table 53-3). Osteopenia, or low bone mass that eventually may lead to osteoporosis, is defined as a T-score between -2.5 and -1.0 standard deviations below the mean. The International Society for Clinical Densitometry recommends use of the WHO definition and T-scores for diagnosis of osteoporosis in postmenopausal women and men... 

The software utilizes a wide variety of information contained in corporate databases to identify interesting compounds with lead-like features. These features of a compound are grouped into several categories and are combined to create scores that define fairly independent measures of a compound s suitability for follow-up evaluation. These scores are then combined to create a composite score that weights the features according to project team objectives. 

One or more lead molecules may be used as a focusing target. Similarity metrics include Daylight fingerprint Tanimoto similarity. The penalty score for each compound in the library is defined as the distance between it and the most similar lead molecule. The penalty score for the library is the average of the individual compound penalty scores. QSAR predictions and docking scores can also be used in this term. 

Direct comparison of IBI scores lends itself to misinterpretation and misuse. It is entirely possible that a regulatory endpoint could be defined by an IBI measurement score of 55 using IBI. Unfortunately, this definition leads to many possible species compositions, and the score is dependent on the assignment of values during the development of the IBI. It would be better to specify just the features of the aquatic system deemed valuable along with target populations as measurement endpoints. 

DeWitte and Shakhnovich developed a mean-force scoring function (SMoG) for de novo lead design using 13 protein and 13 ligand atom types [59]. It was based on a set of contact-based potentials in which a ligand atom is defined as in contact with a protein atom if they are within 5 A from each other. The potential parameter wy was derived from the statistical information about interatomic interactions in crystal structures as... 

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