Lead nephropathy Queensland

Inglis JA, Henderson DA, Emmerson BT. The pathology and pathogenesis of chronic lead nephropathy occurring in Queensland. J Path 1978 124 65-76. 

Craswell PW, Price J, Boyle PD, Heazlewood VJ, Baddeley H, Lloyd HM, Thomas BJ, Thomas BW, Williams GM. Chronic lead nephropathy in Queensland alternative methods of diagnosis. Aust NZ J Med 1986 16 11-19. 

Examination of Pb mobilization data through provocative chelation or chelation therapy plumburesis (Chisolm et al., 1976 Emmerson, 1963) showed large bone Pb stores in the Queensland young adults, while bone Pb concentrations in these nephropathy patients years after the lead paint exposures were also quite high. The mean bone Pb content reported by Inglis et al. (1978) for such patients rivals that reported for individuals with high occupational Pb exposures. 

Lead-induced nephropathy was first reported more than a century ago. However, the condition remains to be clearly defined. A study from Queensland, Australia, described 34 patients with a chronic nephropathy who had suffered from lead palsy in childhood following exposure to lead paints (Nye, 1933). Interstitial fibrosis, tubular atrophy and dilation have been observed in workers with heavy long-term exposure to lead. Renal tubular dysfunction characterized by glycosuria and aminoaciduria has been observed in lead-exposed children (Chisholm and Leahy, 1962). Lead exposure should be considered in the differential diagnosis of glycosuria occurring in childhood. 

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