Lasso peptides

The lasso peptides [LI 14] are bacterial defense peptides, which present a lasso structure, that is, in the form of a loop similar to the lasso of a cowboy. This structure is achieved by the formation of a macrocycle (solid arrow in Figure 9.1) at one end of the amino acids chain, in which is inserted and... 

Figure 9.1. Microcine J25, a lasso peptide produced by the enterobacteria Escherichia coli (solid arrow macrolactame cycle, dashed arrow peptidic tail) (http //www2.cnrs.fr/presse/communique/2651.htm debut=48)...

LI 14] Li Y., Zirah S., Rebuffat S., Lasso Peptides Bacterial Strategies to Make and Maintain Entangled Scaffolds, Springer-Verlag, 2014. 

PIS 15] Piscotta F.J., Tharp J.M., Liu W.R. et al, Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids , Chemical Communications, vol. 51, pp. 409—412, 2015. 

The class II lasso peptide RES-701-1 (35, Figure 8.13) is a potent ETb receptor selective antagonist which was isolated from the fermentation broth of Streptomyces sp. It inhibits the [ I]-ET-1 binding to the ETb receptor expressed in CHO cells with IC50 of 10 nM (ETa ICso>5000 nM). It reduces... 

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