Laron-type dwarfism

E4. Eshet, R., Laron, Z., Pertzelan, A., Amon, R., and Dintzman, M., Defect of human growth hormone receptors in the liver of two patients with Laron-type dwarfism. Isr. J. Med. Sci. 20, 8-11 (1984). 

Such effects render IGFs likely therapeutic candidates in treating the various forms of dwarfism caused by a dysfunction in some element of the GH-IGF growth axis. Initial trials show that s.c. administration of recombinant human IGF-I over a 12-month period significantly increases the growth rate of Laron-type dwarfs. 

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