Lariat ethers ammonium cation binding

Intramolecularity in lariat ether complexation was demonstrated in three ways. First, when solution cation binding constants were determined. Kg was shown to be independent of cation and macrocycle concentrations (within certain limits). The efficacy of complexation of a single cation by two macrorings [(ML2) complex formation] should be concentration dependent. Second, ammonium cation binding constants were determined for the series (see above) of monoaza-15-crown-5 and -18-crown-6 compounds having (CH2CH20)jiClH3 (n 0 to 8) sidearms (31). 

Shultz et al (1985) 12-, 15-, and 18-Membered-ring nitrogen-pivot lariat ethers syntheses, properties, and sodium and ammonium cation binding properties. 1 Am Chem Soc 107 6659-6668... 

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