Large scale modeling, cellular metabolism

Consequently, we have to touch upon at least some operational issues to define our approach to the ways and means of constructing models of metabolism. At the most basic level, surveying the current literature, we face a strong dichotomy between a quest for elaborate large-scale models of cellular pathways and minimal (skeleton) models, tailored to explain specific dynamic phenomena only. 

Large-scale regulatory network reconstructions can be converted to in silico models that allow systematic analysis of network behavior in response to changes in environmental conditions. These models can be combined further with genome-scale metabolic models to build integrated models of cellular function including both metabolism and its regulation [41]. 

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