Large Animal In vivo Studies

Evaluation of steroid (methylprednisolone or budesonide] treatment for phosgene induced lung injury  

Study 2 multiple inhaled doses Phosgene + glucose saline (n = 6) 

Study 1 single intravenous dose Phosgene + glucose saline n = 6) 

Neither steroid had an effect on mortality, lung oedema, or shunt fraction. However, some beneficial effects on cardiac parameters, e.g. stroke volume, left ventricular stroke work, were noted Steroids were neither beneficial nor detrimental in the treatment of phosgene induced lung injury 

Evaluation of fi-agonist (salbutamol) treatmentforphosgene induced lung injury  

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