Roxithromycin Lansoprazole

Pohle T, Stoll R, Kirchner T, Keep M, Lehn N, Bock H, Domschke W. Eradication of Helicobacter pylori with lansoprazole, roxithromycin and metronidazole—an open pilot study. Aliment Pharmacol Ther 1998 12(12) 1273-8. 

The effect of lansoprazole on roxithromycin concentrations in plasma and gastric tissue have been investigated in 12 healthy volunteers who took lansoprazole 30 mg bd with or without roxithromycin 300 mg bd over 6 days (3). The medications were well tolerated, with only mild adverse events. The more frequent adverse events were nausea, bloating, and diarrhea. Lansoprazole and roxithromycin did not alter the systemic availability of each other. However, lansoprazole increased the local concentration of the antibiotic in the stomach. 

A study of roxithromycin 300 mg twice daily with omeprazole 20 mg twice daily or with lansoprazole 30 mg twice daily, for 6 days found that neither PPI significantly affected the pharmacokinetics of roxithromycin. ... 

The pharmacokinetic interactions between clarithromycin and omeprazole, esomeprazole and lansoprazole are established. However, none of the changes reported represents an adverse interaction, but they may help to explain why concurrent use is valuable in the eradication of Helicobacter pylori. Erythromycin is likely to interact similarly, whereas roxithromycin does not. Pantoprazole is not affected by macrolides. 

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