Lansoprazole Digoxin

There is a decreased absorption of lansoprazole when it is administered with sucralfate Lansoprazole may decrease tiie effects of ketoconazole, iron salts, and digoxin. When lansoprazole is administered with theophylline, there is an... 

Transporter efflux transporter effects predominant Examples Amiodarone Atorvastatin Azithromycin Carbamazepine Carvediioi Chlorpromazine Ciprofloxacin Cisapride Cyciosporine Danazoi Dapsone Diclofenac Diflunisal Digoxin Erythromycin Flurbiprofen Glipizide Glyburide Griseofulvin Ibuprofen Indinavir Indomethacin Itraconazole Ketoconazole Lansoprazole Lovastatin Mebendazole Naproxen Nelfinavir Ofloxacin Oxaprozin Phenazopyridine Phenytoin Piroxicam Raloxifene Ritonavir Saquinavir Saquinavir Sirolimus Sirolimus Spironolactone Spironolactone Tacrolimus Tacrolimus ... 

A preliminary report, giving few details, states that rabeprazole increased the minimum digoxin levels by about 20%, and increased the AUC and maximum level. The US manufacturer states that rabeprazole increased the AUC and maximum level of digoxin by 19%, and 29%, respectively. However, these changes are thought to be within the normal variations of digoxin levels and so are not considered clinically significant. See also Lansoprazole, above. 

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