Laidlaw

These results indicate that in these new ester mydriatics, the structural factors, which influence the development of this type of pharmacological action are similar to those made evident by the chemical investigations of Jowett and Pyman and the pharmacological work of Marshall, Dale, Laidlaw and Cushny on the tropeines. The nature of the basic component is obviously important since mydriasis is produced by simple bases such as ephedrine. As regards the nature of the esterifying acid, Jowett and Pyman drew the following conclusions — ... 

Canadine is bitter and in small doses causes drowsiness and depression. In large doses it gives rise to transient excitement succeeded by depression and paralysis of the central nervous system. Its injection is followed by violent peristalsis with diarrhoea. It is said to have no effect on the blood pressure. The pharmacological action of canadine a- and -meihochlorides was examined by Laidlaw, who found both to have the curare-like action common to ammonium bases, the -isomeride being the more active the relative activities of the four optically active forms are given as h da. ip dp = 1 Q 2 28. 

Laidlaw, R. A. and Pinion, L. C., Metal Plate Fasteners in Trussed Rafters Treated with Preservatives of Flame Retardants-Corrosion Risks, IS 11/77, Building Research Establishment (1977)... 

Water-Tracing Compounds. Another application of these fluorescent pyridones has been the development of a series of coaipounds useful as ground-water tracers. Smart and Laidlaw have outlined several qualities desirable in fluorescent water-tracing compounds (.18). 

In tests conducted by Smart and Laidlaw, adsorption was the least prevalent in compounds containing sulfonic acid groups. This seemed to be due to their low pK, which gives an anionic group that repels the usual anionic charges of the adsorbents. 

The quantity and distribution of soil Pb have been studied in numerous places in North America (see Laidlaw Filippelli, 2008). All these North American cities exhibited the same distance decay characteristic of high soil Pb contamination in the inner city and decreasing contamination toward the outer parts of the city as initially identified... 

Soil lead concentrations have been observed to be associated with children s blood lead concentrations using multiple study designs - cross-sectional, ecological spatial, ecological temporal, prospective soil removal and isotopic (Laidlaw Filippelli, 2008). 

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