Lactose, total synthesis

Peng George Wang and coworkers reported [69] the total synthesis of iGb3Cer by using the azidosphingosine glycosylation procedure (Scheme 12.7). The lactosyl 3 -OH acceptor 34 was prepared from lactose via anomeric benzylation, tin-mediated... 

The conversion of the synthetic 4-(/3-D-galactopyranosyl)-D-mannose (epilactose) through the hexaacetyllactal to lactose forms the keystone in the total synthesis of this sugar.61-62 Proof of the structure of 4-(/3-D-gal-actopyranosyl)-D-mannose was accomplished by hydrolyzing it with hydrochloric acid, and also with emulsin, to D-galactose (identified by oxidation to mucic acid) and D-mannose (identified as its phenylhydrazone).18... 

Milk from cows with mastitic infections contains a low level of total solids, especially lactose, and high levels of sodium and chloride, the concentration of which are directly related (Figure 5.5). The sodium and chloride ions come from the blood to compensate osmotically for the depressed lactose synthesis or vice versa. 

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