Lactose chloride-phosphorus pentachloride

Subsequent to the synthesis of o-altrose in 1910, no further work on altrose was reported until 1926. In the preceding year, Hudson and Kunz had prepared acetochloro-a-lactose by boiling gently for one and one-half hours a mixture of 20 g. of octaacetyllactose in 100 ml. of chloroform with 10 g. of phosphorus pentachloride and 5 g. of anhydrous aluminum chloride the pure product, isolated in the usual way, consisted of needles, m. p. 120-121 , and +83.9 in chloroform. On one... 

In the reaction of lactose octaacetate (258) with phosphorus pentachloride and aluminum trichloride, Hudson and Kun found, in addition to the anticipated hepta-O-acetyl-lactosyl chloride, a new disaccharide derivative having the structure of the heptaacetate of 4-O-jS-D-galactopyranosyl-a-D-altropyranosyl chloride (259). The yield of 259 was raised to 35-40% when 50 grams of octa-O-acetyl-lactose (258) was heated for 20 minutes with 100 grams of aluminum... 

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