Lactobacillus bulgaricus factor

Coenzyme A. CoA. C HjjNjO PjS mol wt 767.55. C 32.86%, H 4.73%, N 12.78%, O 33.35%, P 12.11%, S 4.18%, A co-factor in enzymatic acetyl transfer reactions. The molecule is built up from pantetheine [Lactobacillus bulgaricus factor consisting of pantothenic acid and cyste-amine (thioethylamine 0-mercaptoethylamine decarboxyl -ated cysteine)], adenosine, and phosphoric acid. Iscln from... 

One of the first findings which gave a definite clue to the functioning of pantothenic acid in biological systems was the discovery of its presence as a fundamental constituent of coenzyme A. Initially preparations of this coenzyme failed to yield pantothenic acid, but in the author s laboratory a sample of coenzyme submitted by Dr. Lipmann was found to yield on acid hydrolysis a substantial amount of / -alanine , a fact strongly suggesting the presence of pantothenic acid, which was itself later released by enzymatic action . A further link in the chain was revealed in the discovery of pantothiene (the Lactobacillus bulgaricus factor) which has the formula indicated ... 

Lactobacillus bulgaricus Factor, Pantethine and Related Forms of... 

The chemical structure of coenzyme A is considerably more complex than that of the preceding coenzymes. It is helpful to divide it mentally into adenosines, 5 -diphosphate and pantetheine phosphate. Pantetheine is a growth factor for several microorganisms, e.g. Lactobacillus bulgaricus. It, in turn, consists of pantoic acid, 3-alanine, and mercaptoethylamine, the decarboxylation product of cysteine. The pantetheine component of CoA therefore contains three constituents in amide linkage. 

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