Lactams, Penicillins, Cephalosporins, and Related Compounds

A comprehensive review covering the synthesis and biological acti- 

The formation of B-lactams by reaction of ester enolates with 

Reaction of the dianion of ethyl (S)-e-hydroxybutyrate (371) with a range of imines continues to be employed by several groups as a route to 3-(1-hydroxyethyl)-2-azetidinones. In a continuation of their preliminary studies published last year, Hart et al. have now reported that reaction of the dianion of (371) with the imine 

As an alternative procedure to the reaction of N-trimethylsilyl-imines with ester enolates Colvin et al. have now reported that silyl ketene acetals can be employed in a one-pot synthesis of - 

Four interesting new procedures for formation of monocyclic B-lactams via N-C(4) or C(3)-C(4) closure have been reported. Hanesslan et al. have demonstrated that the imidazolylsulphonate group is an efficient leaving group in the ring closure of N- 

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