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Lactams hydrogenation

Hypoiodite oxidation of 5-amino-5-deoxy-D-glucopyranose (45) gives 5-amino-5-deoxy-D-glucono-l,5-lactam. Hydrogenation (over... [Pg.165]

The cyclizations yield mostly the more stable epi-derivatives (e.g. (151)), with trans stereochemistry of the 0-lactam hydrogens. Nucleophilic displacement of the 7a-bromo substituent with thallium(I) phthalimide therefore results in the formation of the c/s derivative (153) [109,110]. [Pg.207]

The cyclic carbonate of benzoin (4,5-diphenyl-l,3-dioxol-2-one, prepared from benzoin and phosgene) blocks both hydrogen atoms of primary amines after dehydration acid stable, easily crystallizable Sheehan oxazolinones are formed, which are also called Ox derivatives. The amine is quantitatively deblocked by catalytic hydrogenation in the presence of 1 equiv. of aqueous acid (J.C Sheehan, 1972, 1973 M.J. Miller, 1983). An intelligent application to syntheses of acid labile -lactams is given in the previous section (p. 161). [Pg.164]

APA may be either obtained directly from special Penicillium strains or by hydrolysis of penicillin Q with the aid of amidase enzymes. A major problem in the synthesis of different amides from 6-APA is the acid- and base-sensitivity of its -lactam ring which is usually very unstable outside of the pH range from 3 to 6. One synthesis of ampidllin applies the condensation of 6-APA with a mixed anhydride of N-protected phenylglydne. Catalytic hydrogenation removes the N-protecting group. Yields are low (2 30%) (without scheme). [Pg.311]

Without other alternatives, the carboxyalkyl radicals couple to form dibasic acids HOOC(CH)2 COOH. In addition, the carboxyalkyl radical can be used for other desired radical reactions, eg, hydrogen abstraction, vinyl monomer polymerization, addition of carbon monoxide, etc. The reactions of this radical with chloride and cyanide ions are used to produce amino acids and lactams employed in the manufacture of polyamides, eg, nylon. [Pg.113]

Cross-linked PVP can also be obtained by cross-linking the preformed polymer chemically (with persulfates, hydrazine, or peroxides) or with actinic radiation (63). This approach requires a source of free radicals capable of hydrogen abstraction from one or another of the labile hydrogens attached alpha to the pyrrohdone carbonyl or lactam nitrogen. The subsequently formed PVP radical can combine with another such radical to form a cross-link or undergo side reactions such as scission or cyclization (64,65), thus ... [Pg.526]


See other pages where Lactams hydrogenation is mentioned: [Pg.4]    [Pg.75]    [Pg.84]    [Pg.161]    [Pg.111]    [Pg.125]    [Pg.865]    [Pg.832]    [Pg.161]    [Pg.832]    [Pg.832]    [Pg.4]    [Pg.75]    [Pg.832]    [Pg.816]    [Pg.4]    [Pg.75]    [Pg.84]    [Pg.161]    [Pg.111]    [Pg.125]    [Pg.865]    [Pg.832]    [Pg.161]    [Pg.832]    [Pg.832]    [Pg.4]    [Pg.75]    [Pg.832]    [Pg.816]    [Pg.261]    [Pg.48]    [Pg.496]    [Pg.360]    [Pg.522]    [Pg.530]    [Pg.271]    [Pg.273]    [Pg.273]    [Pg.240]    [Pg.251]    [Pg.265]    [Pg.278]    [Pg.287]    [Pg.305]    [Pg.488]    [Pg.141]    [Pg.141]    [Pg.144]    [Pg.145]    [Pg.145]    [Pg.146]    [Pg.150]    [Pg.530]    [Pg.530]    [Pg.530]    [Pg.567]    [Pg.581]   
See also in sourсe #XX -- [ Pg.7 ]

See also in sourсe #XX -- [ Pg.178 ]




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