Lactams chiral five-membered

Over the last years, one of the most studied DCR has been the asymmetric version of the cycloaddition of nitrones with alkenes. This reaction leads to the construction of up to three contiguous asymmetric carbon centers (Scheme 4). The resulting five-membered isoxazolidine derivatives may be converted into amino alcohols, alkaloids, or p-lactams. Several chiral metal complexes have been used as catalysts for this process [13-15, 18-22]. However, the employment of iridium derivatives is very scarce. 

Taking advantage of the bulky f-butyl group of methyl )V-((o-bromoacyl)-l -butyl-oxazolidine-4-carboxylate to achieve a 1,3-asymmetric induction in the i- ramolecular alkylation, a series of lactams containing a quaternary chiral center is i. jilable. With S AMP/RAMP chiral auxiliaries, the synthesis of 2-substituted (five, six, and. en membered) lactams is readily achieved." Aldehyde hydrazones of this series undergo iANtereoselective phosphinylation. ... 

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