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3-Lactamase

Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989). Molecular Cloning. A Laboratory Manual, 2nd ed. CSHL Press, Cold Spring Harbor, New York. [Pg.595]

Geiger, R., Schneider, E., Wallenfels, K., and Miska, W. (1992). Biol. Ghent. Hoppe-Seyler. 373, 1187-1191. [Pg.595]

Primarily due to their clinical importance, /3-lactamases have been extensively studied with respect to enzyme structure, function, induction, secretion, and transfer of genetic elements. The wealth of biological, biochemical, and genetic information of the /3-lactamases and their genes (e.g., bla) has led to the use of the bla system as one of the most important selection marker/reporters in recombinant DNA technology. [Pg.596]

The amino acid numbering for class A /8-lactamases conventionally follow the numbering scheme (class A /8-lactamase or ABL scheme) which is based on the sequence alignment of 20 class A /8-lactamases (6). [Pg.597]

FIGURE 8.4 General reaction of /3-lactamases and structures of typical /8-lactam substrates. (I) and (II) penicillin(s) and penicilloic acid pair. (Ill) and (IV) cephalosporin(s) and cephalosporoic acid pair. R denotes the side chain on 6-APA or 7-ACA, and R denotes the side chain on the C-3 position of cephalosporins. [Pg.598]

Strynadka et al., 1996] Strynadka, N., Eisenstein, M., Katchalski-Katzir, E., Shoichet, B., Kuntz, I., Abagyan, R., Totrov, M., Janin, J., Cherflls, J., Zimmerman, F., Olson, A., Duncan, B., Rao, M., Jackson, R., Sternberg, M., and James, M. Molecular docking programs successfully predict the binding of a /3-lactamase inhibitory protein to TEM-1 /3-lactamase. Nature Struct. Biol. 3 (1996) 233-239... [Pg.64]

ANTIBIOTICS - BETA-LACTAMS - BETA-LACTAMASE INHIBITORS] (Vol 3)... [Pg.15]

ANTTBIOTTCS - BETA-LACTAMS - BETA-LACTAMASE INHIBITORS] (Vol 3) -genetic engineering host [GENETIC ENGINEERING - MICROBES] (Vol 12)... [Pg.84]

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3-lactamases

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