Label-free technology

Xi B. 2008. The application of cell-based label free technology in drug discovery. Biotechnol. J. 3, 484-495. 

In the field of proteomics, especially protein microarrays, there have been numerous advancements in both label-based and label-free technologies, which are discussed in the following sections. 

Cooper M, Mayr LM, Rich RL, Myszka DG (2011) The revolution of real-time, label-free biosensor applications. In Cooper M, Mayr LM (eds) Label-free technologies for drug discovery. Wiley, New York... 

Shiau, A.K., Massari, M.E., and Ozbal, C.C. (2008) Back to basics label-free technologies for small molecule screening. Combinatorial Chemistry... 

R362 S. Gul, The Application of Label-Free Technologies in Drug Discovery for Soluble Protein Targets , Int. Drug Discovery, 2011, 6, 24. 

Label-fi ee strategies provide an alternative route for circumventing the above-mentioned difficulties with respect to protein microarray detection. Currently, relatively few label-fi-ee detection methods such as mass spectrometry (MS) (2,3), surface plasmon resonance (SPR) (4) and atomic force microscopy (AFM) (5,6) are applicable to the microarray format. These label-free technologies require the use of sophisticated tools that are not available in all bioanalytical laboratories. 

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