L- retro

The combination of the nonpalindromic nature of the peptide backbone and the chirality of the a-carbons in the amino acids comprising the oligomeric structure provides a unique opportunity for vast stereochemical and topochemical diversities. Earlier studies explored the interesting structural relationship between all-L-, retro-all-L-peptides, and their enantiomers (see reviews[1 3]). Schematically, a high degree of topochemical complementarity is obtained between parent cyclic peptides and their retro-inverso analogues.11 ... 

Scheme 72 A cyclobutadiene surrogate for the PKR. Tandem [2 + 2 + l]/retro Diels-Alder...

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