L-Orni thine

This enzyme [EC 2.1.3.3], also known as ornithine car-bamoyltransferase and citrulline phosphorylase, catalyzes the reaction of carbamoyl phosphate with L-orni-thine to produce L-citrulline and orthophosphate. 

N -Hydroxy-L-orni thine ferrichrome Ustilago sphaerogena (43) ... 

Olsen, R.K., K. Ramasamy, and T. Emery Synthesis of N ,N -Hydroxy-L-orni-thine from L-Glutamic Acid. J. Organ. Chem. (USA) 49, 3527 (1984). 

In contrast to the system of Shimura et al. (1964), intact protoplasts of strain 10716 require six amino acids for production of bacitracin and, for maximal yield, glucose is needed. Disrupted protoplasts are unable to synthesize the antibiotic (Snoke, 1961). With protoplasts, the six needed amino acids are L-cysteine, L-isoleucine, L-leucine, L-histidine, L-ornithine, and L-asparagine. Neither D-orni-thine nor D-asparagine can be utihzed directly and D-phenylalanine inhibits formation of bacitracin in the absence of L-phenylalanine. A peptide factor in soybean was found to be stimulatory for synthesis of bacitracin by whole cells provided that D-phenylalanine is present in the reaction mixture (Snoke, i960, 1961). In the absence of the D-amino acid, the peptide factor is inactive. 

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