L’abbe

L abbe and coworkers studied the synthesis and thermolysis of 5-azido-4-formyl-oxazoles. They found, for example, that azides 17a-b rearrange at room temperature to yield isolable, isomeric oxazoles 18a-b. 

BSB1007 G. L abbe, P. Delbeke, G. Van Essche, I. Luyten, K. Vercauteren,... 

MRC362 G. L abbe, M.-A. Persoons, and S.Toppet, Magn. Reson. Chem. 25,... 

L abbe has studied the rearrangement reactions of 1,2,3-thiadiazoles to differently substituted 1,2,3-thiadiazoles <1983CC588>. He also studied many 5-azido-l,2,3-thiadiazoles 33 that rearranged to 1,2,3,4-thiatriazoles 34 (Equation 5) <1988BSB163>. He even found that l,2,3-thiadiazole-4-carboxaldehydes 35 upon treatment with amines underwent thermal rearrangement to 1,2,3-triazoles 36 (Equation 6) <1993J(P1)1719>. 

Figure 8.17 Copper-trafficking pathways within a mammalian cell. Regulation by copper deficiency (arrows connected by dotted lines) or overload (arrows connected by sobd lines) as currently understood. (From Bertinato and L Abbe, 2004. Copyright 2004, with permission from Elsevier.)...

Bertinato, J. and L Abbe, M.R. (2004) Maintaining copper homeostasis regulation of copper-trafficking proteins in response to copper deficiency or overload, J. Nutr. Biochem., 15, 316-322. 

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