Kyotorphin analogs

The [D-Ser2]- and [Pro2]-neo-kyotorphin analogs synthesized by Kitagawa et al.57) are 10 times as active as native neo-kyotorphin. 

Figure 15.41. Deliveiy of kyotorphin analogs was achieved using both using a chemical delivery system (131) and a brain-targeted redox analog (132) approach.

A strategy for the enhancement of intestinal absorption by derivation into a monosaccharide analog has also been applied to peptides. The coupling of kyotorphin (an unstable peptide) with p-glucoside enhanced the absorption and clearance of kyotorphin in the rat-everted jejunum and... 

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