Monosaccharide analog

Comparison of Sweetness between Trehalose Derivatives and the Corresponding Monosaccharide Analogs by Paired Comparison Test d... 

Preparation of modified, bacterial polysaccharides having monosaccharide analogs inserted into the polymeric chain is of interest for study of the structure-properties relationship in these biopolymers. Incorporation of chemically prepared, modified, biosynthetic precursors of the polymers in enzymic reactions seems a promising approach for achieving this aim. Such an approach, which may be termed chemical-enzymic synthesis, has now been studied by our group,439-441 using O-specific polysaccharides (10-12) of Salmonella serogroups B and E as an example. 

Enzymes Catalyzing C—C Bond Formation for the Synthesis of Monosaccharide Analogs... 

In this section we describe recent syntheses of monosaccharide analogs we have developed with FruA and transketolase (e.g. aminocyclitols, D-xylulose and D-xylose analogs) including the recent syntheses of DHAP, the donor substrate of FruA. 

A strategy for the enhancement of intestinal absorption by derivation into a monosaccharide analog has also been applied to peptides. The coupling of kyotorphin (an unstable peptide) with p-glucoside enhanced the absorption and clearance of kyotorphin in the rat-everted jejunum and... 

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