Kynurenine pathway of tryptophan metabolism in man

Aspects of Disorders of the Kynurenine Pathway of Tryptophan Metabolism in Man... 

ASPECTS OF DISORDERS OF THE KYNURENINE PATHWAY OF TRYPTOPHAN METABOLISM IN MAN... 

Among the existing degradative pathways for tryptophan, one is known as the kynurenine route, Fig. (1). The word kynurenines is used to define the intermediates of this route which account for more than 90% of the whole tryptophan metabolism in man [4], and for 95% of dietary tryptophan [5], So, the intermediates of the kynurenine pathway are quite important quantitatively. Among these, kynurenic and quinolinic acids have been extensively studied as regards their neuroactivities [6-13]. 

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