Ktrlp family

Much information is yet needed before we know how a Man-T distinguishes GDPMan from other sugar nucleotides, and what structural features are correlated with the ability of closely-related Man-T to form different a-mannosidic linkages or to transfer Man-P (as can different members of the Ktrlp family (section 8.4.2)). 

P-Man-T activities involved in modifying cell wall mannan of the fungal genus Candida [69], which includes the human pathogen C. albicans. In Saccharomyces cerevisiae, the genes for the Man-T that add additional a-linked Man to protein-bound GPI anchors in the Golgi may yet be found in the Mnnlp or Ktrlp families. 

---