Kresge model

Application of Marcus rate theory to proton transfer in enzyme-catalyzed reactions was discussed by Kresge and Silverman, 1999. Relationships of log KIE and kinetics of the enzyme catalysis (kcat) and parameters of the reaction driving force were found to be in agreement with the Marcus model. 

According to Kresge s model,the lag in resonance stabilization can be modeled as A/ici o4 = where m = 2 and x is some proportionality... 

ISM encompasses, as particular cases, several current models of chemical reactivity such as the theory of Marcus [18], the BEBO [4a], Agmon and Levine [5a], Koeppl and Kresge [ 19] models and two dimensional models such as the ones of Kreevoy and Lee [20] and of Grunwald [21]. It is also in general accord with qualitative electronic theories of chemical... 

In the same manner the models of Agmon-Levine (eqs(3) to (9)) and the Koeppl-Kresge (eq(34) with a square dependence of d on AG) [4c, 5a] are encompassed by ISM, but neglect the role of the resonance effect, i.e. ni>l/2. Nevertheless, we must point out that in the former model X has a different meaning X is equivalent to the intrinsic kinetic... 

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