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Krebs cycle evolution

There are also voices critical of the rTCA cycle Davis S. Ross has studied kinetic and thermodynamic data and concludes that the reductive, enzyme-free Krebs cycle (in this case the sequence acetate-pyruvate-oxalacetate-malate) was not suitable as an important, basic reaction in the life evolution process. Data on the Pt-catalysed reduction of carbonyl groups by phosphinate show that the rate of the reaction from pyruvate to malate is much too low to be of importance for the rTCA cycle. In addition, the energy barrier for the formation of pyruvate from acetate is much too high (Ross, 2007). [Pg.198]

Baldwin JE, Krebs HA The evolution of metabolic cycles. Nature 1981 291 381. [Pg.135]

E. Melendez-Hevia, T.G. Waddell, and M. Cascante. 1996. The puzzle of the Krebs citric acid cycle Assembling the pieces of chemically feasible reactions, and opportunism in the design of metabolic pathways in evolution J. Mol. Evol. 43 293-303. (PubMed)... [Pg.733]

J.E. Baldwin and H. Krebs. 1981. The evolution of metabolic cycles Nature 291 381-382. (PubMed)... [Pg.733]

See other pages where Krebs cycle evolution is mentioned: [Pg.204]    [Pg.86]    [Pg.154]    [Pg.594]    [Pg.40]    [Pg.2874]    [Pg.1016]    [Pg.499]    [Pg.488]   
See also in sourсe #XX -- [ Pg.9 ]



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