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Kogenate

Kogenate FS Recombinant Solvent detergent, monoclonal antibody Albumin (fermentation only) sucrose... [Pg.990]

KoGENate Antihemophilic factor Bayer corporation Treatment of hemophilia A... [Pg.694]

Helixate—average of 250, 500, or 1000 factor VIII units/vial -Bioclate—average of 250, 500, or 1000 factor VIII units/vial -Kogenate—average of 250, 500, or 1000 factor VIII units/vial -Recombinate—average of 250, 500, or 1000 factor VIII units/vial... [Pg.160]

Blood factors, anticoagulants and thrombolytics Activase, Advate, Benefix, Bioclate, Helixate/ Kogenate, Metalyse/TNKase, Novoseven, Recombinate, Refacto, Xigiris... [Pg.32]

Kogenate (rhFactor VIII) Helixate NexGen (rhFactor VIII) NovoSeven (rhFactor Vila) Recombinate (rhFactor VIII) ReFacto (B-domain deleted rhFactor VIII)... [Pg.335]

Kodel, 20 33, 37 Koenigs-Knorr reaction, 4 704 Kogenate, cell culture technology product, 5 346t... [Pg.505]

Recombinant Bleeding episodes or snrgical NovoSeven, Kogenate,... [Pg.96]

Ori M, Toda N, Takami K, Tago K, Kogen H (2005) Stereospecific synthesis of 2,2,3-trisubstituted tetrahydroquinolines application to the total syntheses of henzastatin E and natural virantmycin. Tetrahedron 61 2075-2104... [Pg.274]

Kogenate (rhFactor VIII produced in BHK cells. Also sold as Helixate by Centeon via a license agreement) Bayer Haemophilia A 1993 (USA), 2000 (EU)... [Pg.499]

Clinical trials have demonstrated excellent efficacy with recombinant human factor VIII concentrates available as Recombinate and Kogenate. These recombinant factor VIII products are purified from the cell culture of plasmids, not viral DNA-transfected hamster cells and therefore do not express viral sequences. The addition of human serum albumin for stabilization, constitutes the sole possible source for human viral contamination. More recently recombinant factor IX has been genetically engineered by insertion of the human factor IX gene into a Chinese hamster ovary cell line. It has been proved to be safe and effective in the treatment of patients with hemophilia B. [Pg.135]

Dosage form Kogenate and Kogenate FS are prepared as sterile, stable, purified, dried concentrates, which require reconsti-... [Pg.150]

Route of administration The reconstituted product must be administered intravenously by either direct syringe injection or drip infusion. Kogenate and Kogenate FS must be administered within 3 hours after reconstitution. [Pg.150]

Pharmacokinetics Pharmacokinetic studies found that the mean biologic half-life of Kogenate (rAHF) was about 13 hours. The mean biologic half-hfe of plasma-derived AHF in the same individuals was 13.9 hours. In a comparative pharmacokinetic study, Kogenate FS was shown to be similar to its predecessor product Kogenate. [Pg.151]

G. Other considerations Antihemophilic factor (recombinant) has been designated an orphan product for use in the treatment or prophylaxis of bleeding in hemophilia A, or prophylaxis before surgery. Bayer makes a version of Kogenate FS that is sold by Aventis Behring under the name Helix-ate Concentrate (Helixate FS). [Pg.151]

Treatment of classic hemophilia (hemophilia A) in which there is a demonstrated deficiency of activity of the plasma clotting factor FVIII (Compared to Kogenate, some patients who developed inhibitors on study with Kogenate-FS continued to manifest a clinical response when inhibitor titers were less than 10 Bethesda units (BU) per ml). [Pg.571]

Kogenate (F VIII) Hemophilia rBHK-21, bleed-feed... [Pg.135]

Antihemophilic factor [factor VIII, AHF] (Alphanate, Bioclate, Helixate, Hemofil M, Koate-HP, Kogenate, Monoclate, Recombinate, others)... [Pg.772]

See other pages where Kogenate is mentioned: [Pg.1010]    [Pg.1010]    [Pg.118]    [Pg.990]    [Pg.1244]    [Pg.186]    [Pg.87]    [Pg.360]    [Pg.31]    [Pg.632]    [Pg.272]    [Pg.76]    [Pg.20]    [Pg.132]    [Pg.366]    [Pg.313]    [Pg.243]    [Pg.7]    [Pg.149]    [Pg.149]    [Pg.150]    [Pg.150]    [Pg.150]    [Pg.151]    [Pg.453]    [Pg.453]    [Pg.454]    [Pg.478]    [Pg.478]    [Pg.501]    [Pg.555]    [Pg.316]   
See also in sourсe #XX -- [ Pg.366 , Pg.499 ]

See also in sourсe #XX -- [ Pg.135 , Pg.149 , Pg.150 ]

See also in sourсe #XX -- [ Pg.3 , Pg.394 , Pg.398 , Pg.399 ]

See also in sourсe #XX -- [ Pg.569 ]



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Kogenate/Helixate

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