Koebner phenomenon

Koebner phenomenon The occurrence of psoriatic lesions due to skin trauma. 

Skin malignancy (78) and Koebner phenomenon (81) have been associated with acupuncture. 

Kirschbaum JO. Koebner phenomenon following acupuncture. Arch Dermatol 1972 106(5) 767. 

Other rarities reported sporadically (but all in more than one case) include the Koebner phenomenon (210), fixed drug eruptions (for example with iotalamate (211)), and delayed reactions of various types. Reports of severe drug eruptions have become more frequent since the introduction of the non-ionic contrast media, but this may simply be due to the fact that in recent years there has been greater awareness of such reactions (SEDA-16, 538) (SEDA-19, 427) (SEDA-22, 502). 

Shah AM, Hutchison SJ. The Koebner phenomenon—an unusual localization of a contrast reaction. Clin Radiol 1990 42(2) 136-7. 

Maydan E +, J Drugs Dermatol 5(8), 804 Koebner phenomenon (psoriasis)... 

The association between trauma and psoriasis was first described by Heinrich Koebner in the i8th century. The Koebner response refers to the development of an overt lesion of psoriasis following an injury to previously normal appearing skin. This new lesion of psoriasis has morphology identical to the injury thus, it is also known as an isomorphic response . Koebner phenomenon tends to occur more commonly in patients with active psoriatic disease (Eyre and Krueger 1991). 

In an epidemiological study of 1253 psoriatic patients, Melski et al. (1983) found that one-third of the study population had a history of Koebner response at sites of physical trauma. These patients were also found to be associated with earlier onset of psoriasis in life and a tendency to flare despite various treatment options. Apart from the limitations of this study, the authors believed that there is indeed a subset of psoriatic patients, in which Koebner phenomenon may be an important marker. Thus, it is important to identify psoriatic patients and discourage them from engaging in jobs in which they will be subject to excessive trauma. 

Lichen planus. Koebner phenomenon may be present in the disease Lichen planus, especially during the acute stage. Several types of trauma may induce isomorphic phenomena, and typical papules will occur in the injured areas. 

Fisher AA, Baran R (1992) Occupational nail disorders with a reference to Koebner s phenomenon. Am J Contact Dermat 3 404-406... 

Cyclic and dibutyryl-cyclic adenosine 3, 5 -monophosphate (cAMP and DB cAMP) were both utilized in the treatment of psoriasis by a Shanghai study group (39 ). 20 patients received cAMP while 49 received DB cAMP. The dosage was up to 80 mg Lm. daily for 20—90 days. Side effects were recorded in 8 patients on cAMP and 47 on DB cAMP. They included malaise, dizziness, chills, drowsiness, nausea, anorexia, blurred vision, abdominal pain, flushing, urticaria, Koebner s phenomenon and local indurar tion. No interruption of treatment was necessary. 

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