Kleinia kleinioides

In last year s Report, reference was made to the discovery of three examples of a new type of pyrrolizidine alkaloid containing the dihydropyrrolizinone ring system. Two closely related acyl-pyrroles have now been detected in aerial parts of Kleinia kleinioides (Sch. Bip.) M. R. F. Taylor by Bohlmann and Knoll. Spectral data on the first pyrrole showed it to be an isomer of senaetnine (29), with different stereochemistry at C-7, C-12, or C-13. Lack of material prevented clarification of the stereochemistry of isosenaetnine (29). The second new compound differed from isosenaetnine in replacement of one methyl group by methylene, and it is therefore formulated as dehydroisosenaetnine (30). The stereochemistry is again uncertain. 

Bohlmann, F., and K.-H. Knoll Zwei neue Acylpyrrole aus Kleinia kleinioides. Phytochemistry 17, 599 (1978). 

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